ACER1 Polyclonal Antibody | G-AB-03619
Gentaur Antibodies
- SKU:
- G-AB-03619
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
ACER1 Polyclonal Antibody | G-AB-03619 | Gentaur Antibodies
Overview: ACER1 (Alkaline Ceramidase 1) is a Protein Coding gene. Diseases associated with ACER1 include Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and dihydroceramidase activity. An important paralog of this gene is ACER2.Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Metabolism, Signal Transduction
Synonyms: Acer1, ACER1, Acylsphingosine deacylase 3, Alkaline CDase 1, Alkaline ceramidase 1, Alkaline ceramidase, AlkCDase 1, ALKCDase1, ASAH 3, MGC138327, MGC138329, N acylsphingosine amidohydrolase (alkaline ceramidase) 3, N acylsphingosine amidohydrolase 3 alkaline ceramidase, N acylsphingosine amidohydrolase 3, N-acylsphingosine amidohydrolase 3
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: NP597999
Clonality: Polyclonal
Immunogen: Synthetic peptide of human ACER1
Clone #:
Conjugation: Unconjugated
Swissprot: Q8TDN7
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1.2 mg/mL
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification method: Antigen affinity purification
Application: IHC, ELISA
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
1 Review Hide Reviews Show Reviews
-
outstanding
their , response, shipping and the way they deliver their products safely is outstanding