AIFM1 Polyclonal Antibody | G-AB-00443

AIFM1 Polyclonal Antibody | G-AB-00443 | Gentaur Antibodies

Overview: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism

Synonyms: AIFM1, AIFM1, Apoptosis inducing factor 1, mitochondrial, Apoptosis inducing factor, Apoptosis inducing factor, mitochondrion associated, 1, Apoptosis-inducing factor 1, CMTX4, COWCK, COXPD6, Harlequin, Hq, mAIF, MGC111425, MGC5706, mitochondrial, Neuropathy, axonal motor-sensory, with deafness and mental retardation, neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome) , PDCD 8, PDCD8, Programmed cell death 8 (apoptosis inducing factor) , Programmed cell death 8, Programmed cell death 8 isoform 1, Programmed cell death 8 isoform 2, Programmed cell death 8 isoform 3, Programmed cell death protein 8, Programmed cell death protein 8 mitochondrial, Programmed cell death protein 8 mitochondrial precursor, Programmed cell death protein 8 mitochondrial precursor, Striatal apoptosis inducing factor

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC139738

Clonality: Polyclonal

Immunogen: Recombinant protein of human AIFM1

Clone #:

Conjugation: Unconjugated

Swissprot: O95831

Santa Cruz: sc-9417/sc-9416/sc-5586

Calculated MW: 67 kDa

Observed MW:

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

AIFM1 Polyclonal Antibody DataSheet