ALKBH8 Polyclonal Antibody | G-AB-11528

ALKBH8 Polyclonal Antibody | G-AB-11528 | Gentaur Antibodies

Overview: ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: ALKBH8, ABH8, TRM9, TRMT9

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 91801

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ALKBH8 (NP_620130.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q96BT7

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:100-1:200 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ALKBH8 Polyclonal Antibody DataSheet