ATP6V1B1 Polyclonal Antibody | G-AB-11351

ATP6V1B1 Polyclonal Antibody | G-AB-11351 | Gentaur Antibodies

Overview: This gene encodes a component of vacuolar ATPase (V-ATPase) , a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: ATP6V1B1, ATP6B1, RTA1B, VATB, VMA2, VPP3

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 525

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ATP6V1B1 (NP_001683.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P15313

Santa Cruz:

Calculated MW: 56 kDa

Observed MW: 57 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ATP6V1B1 Polyclonal Antibody DataSheet