BCR Polyclonal Antibody | G-AB-00373

BCR Polyclonal Antibody | G-AB-00373 | Gentaur Antibodies

Overview: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction, Cancer

Synonyms: ALL, bcr, BCR1, Breakpoint cluster region, CML, D22S11, D22S662, PHL, Renal carcinoma antigen NY-REN-26

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 110279

Accession #:

Clonality: Polyclonal

Immunogen: Recombinant Mouse Breakpoint cluster region protein

Clone #:

Conjugation: Unconjugated

Swissprot: Q6PAJ1

Santa Cruz:

Calculated MW: 143 kDa

Observed MW: 143 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3

Purification method: Antigen Affinity Purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

BCR Polyclonal Antibody DataSheet