beta Amyloid Polyclonal Antibody | G-AB-05317

beta Amyloid Polyclonal Antibody | G-AB-05317 | Gentaur Antibodies

Overview: Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein (APP) , encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience

Synonyms: A4 amyloid protein, A4, AAA, ABETA, ABPP, AD1, AICD-50, AICD-57, AICD-59, AID (50) , AID (57) , AID (59) , Alzheimer disease amyloid protein, Amyloid beta (A4) precursor protein, Amyloid beta A4 protein, Amyloid beta protein, Amyloid intracellular domain 50, Amyloid intracellular domain 57, Amyloid intracellular domain 59, Amyloid precursor protein, APP, APPI, Beta amyloid peptide, Beta-amyloid precursor protein, Beta-APP40, Beta-APP42, C31, Cerebral vascular amyloid peptide, CTFgamma, CVAP, Gamma-CTF (50) , Gamma-CTF (57) , Gamma-CTF (59) , peptidase nexin II, PN 2, PN II, PN-II, PN2, PreA4, Protease nexin II, Protease nexin-II, S-APP-alpha, S-APP-beta

Reactivity: Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse APP

Clone #:

Conjugation: Unconjugated

Swissprot: P12023, P08592

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 130 μg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:200-1:800

Storage: Store at -20°C. Avoid freeze / thaw cycles.

beta Amyloid Polyclonal Antibody DataSheet