BORA Polyclonal Antibody | G-AB-08450
Gentaur Antibodies
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Gentaur Antibodies
BORA Polyclonal Antibody | G-AB-08450
- SKU:
- G-AB-08450
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
BORA Polyclonal Antibody | G-AB-08450 | Gentaur Antibodies
Overview: Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cell Biology, Signal Transduction
Synonyms: BORA, C13orf34
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID: 79866
Accession #:
Clonality:
Immunogen: Recombinant fusion protein of human BORA (NP_079084.3) .
Clone #:
Conjugation: Unconjugated
Swissprot: Q6PGQ7
Santa Cruz:
Calculated MW: 53 kDa/61 kDa
Observed MW: 90 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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