CAB39 Polyclonal Antibody | G-AB-01776

CAB39 Polyclonal Antibody | G-AB-01776 | Gentaur Antibodies

Overview: Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha) . STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: Cab39, CAB39, Calcium binding protein 39, Calcium-binding protein 39, CGI 66, CGI-66, CGI66, MO25 alpha, MO25, Mouse protein 25 alpha, Protein Mo25

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_057373

Clonality: Polyclonal

Immunogen: Synthetic peptide of human CAB39

Clone #:

Conjugation: Unconjugated

Swissprot: Q9Y376

Santa Cruz:

Calculated MW: 40 kDa

Observed MW:

Concentration: 1.7 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CAB39 Polyclonal Antibody DataSheet