CAB39 Polyclonal Antibody | G-AB-09322
Gentaur Antibodies
- SKU:
- G-AB-09322
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
CAB39 Polyclonal Antibody | G-AB-09322 | Gentaur Antibodies
Overview: Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha) . STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK) .
Category Type: Polyclonal Antibody
Research Areas: Cancer, Metabolism, Signal Transduction
Synonyms: CAB39, CGI-66, MO25
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID: 51719
Accession #:
Clonality:
Immunogen: A synthetic peptide of human CAB39 (NP_001124321.1) .
Clone #:
Conjugation: Unconjugated
Swissprot: Q9Y376
Santa Cruz:
Calculated MW: 39 kDa
Observed MW: 35 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.