CASP3 Polyclonal Antibody | G-AB-05507
Gentaur Antibodies
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Gentaur Antibodies
CASP3 Polyclonal Antibody | G-AB-05507
- SKU:
- G-AB-05507
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
CASP3 Polyclonal Antibody | G-AB-05507 | Gentaur Antibodies
Overview: Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7) , which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 (also named CPP32, SCA-1, and Apopain) proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at the beginning of apoptosis. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience
Synonyms: A830040C14Rik, Apopain, CASP-3, CASP3, CASP3, Casp3a, Caspase 3, Caspase 3, apoptosis-related cysteine peptidase, Caspase 3, apoptosis-related cysteine protease, Caspase 3, apoptosis-related cysteine protease a, Caspase-3 subunit p12, CC3, CPP-32, CPP32, CPP32B, Cysteine protease CPP32, EC 3.4.22.56, LICE, mldy, OTTHUMP00000165052, OTTHUMP00000165053, OTTHUMP00000165054, PARP cleavage protease, Procaspase3, Protein Yama, SCA 1, SCA-1, SREBP cleavage activity 1, Yama
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #:
Clonality: Polyclonal
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse caspase3
Clone #:
Conjugation: Unconjugated
Swissprot: P70677, P42574, P55213
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 500 μg/mL
Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Purification method: Affinity purification
Application: IHC
Dilution: IHC 1:200-1:800
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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