Caspase-8 Polyclonal Antibody | G-AB-07132

Caspase-8 Polyclonal Antibody | G-AB-07132 | Gentaur Antibodies

Overview: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism

Synonyms: ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, Caspase 8, CASP8, Caspase-8, caspase-8

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 841

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human Caspase-8 (NP_001073593.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q14790

Santa Cruz:

Calculated MW: 25-32 kDa/45- 61 kDa

Observed MW: 17 kDa/44 kDa/60 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Caspase-8 Polyclonal Antibody DataSheet

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