CBFA2T2 Polyclonal Antibody | G-AB-11453

CBFA2T2 Polyclonal Antibody | G-AB-11453 | Gentaur Antibodies

Overview: In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: CBFA2T2, EHT, MTGR1, ZMYND3, p85

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 9139

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CBFA2T2 (NP_005084.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O43439

Santa Cruz:

Calculated MW: 28 kDa/63 kDa/65 kDa/67 kDa

Observed MW: 72 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CBFA2T2 Polyclonal Antibody DataSheet