CBFB Polyclonal Antibody | G-AB-10584

CBFB Polyclonal Antibody | G-AB-10584 | Gentaur Antibodies

Overview: The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2) . The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv (16) (p13q22) ] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: CBFB, PEBP2B

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 865

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CBFB (NP_001746.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13951

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CBFB Polyclonal Antibody DataSheet