CBL Polyclonal Antibody | G-AB-07225

CBL Polyclonal Antibody | G-AB-07225 | Gentaur Antibodies

Overview: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many Signal Transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: C-CBL, CBL2, FRA11B, NSLL, RNF55, CBL, c-Cbl

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 867

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CBL (NP_005179.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P22681

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:50-1:100 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CBL Polyclonal Antibody DataSheet