CCM2 Polyclonal Antibody | G-AB-11164

CCM2 Polyclonal Antibody | G-AB-11164 | Gentaur Antibodies

Overview: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Neuroscience, Signal Transduction

Synonyms: CCM2, C7orf22, OSM, PP10187

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 83605

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CCM2 (NP_113631.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9BSQ5

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CCM2 Polyclonal Antibody DataSheet