CD10 Polyclonal Antibody | G-AB-01441

CD10 Polyclonal Antibody | G-AB-01441 | Gentaur Antibodies

Overview: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology, Stem Cells

Synonyms: Atriopeptidase, CALLA, CD10, CD10 antigen, Common acute lymphocytic leukemia antigen, DKFZp686O16152, EC 3.4.24.11, Enkephalinase, EPN, Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) , Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) , Membrane metallo endopeptidase, Membrane metallo endopeptidase variant 1, Membrane metallo endopeptidase variant 2, Membrane metalloendopeptidase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10, Membrane metalloendopeptidase variant 1, Membrane metalloendopeptidase variant 2, MGC126681, MGC126707, MME, NEP, NEP, Neprilysin, neprilysin-390, neprilysin-411, Neutral endopeptidase 24.11, Neutral endopeptidase, Neutral endopeptidase, membrane-associated, SFE, Skin fibroblast elastase

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_000893

Clonality: Polyclonal

Immunogen: Synthetic peptide of human MME

Clone #:

Conjugation: Unconjugated

Swissprot: P08473

Santa Cruz: sc-9149/sc-102424/sc-102426

Calculated MW: 86 kDa

Observed MW:

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CD10 Polyclonal Antibody DataSheet