CD22 Polyclonal Antibody | G-AB-00317

CD22 Polyclonal Antibody | G-AB-00317 | Gentaur Antibodies

Overview: CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule) , is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2, 6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology, Stem Cells

Synonyms: B cell receptor CD22 precursor, B lymphocyte cell adhesion molecule, BL CAM, CD 22, CD22 antigen, CD22 molecule, Lectin 2, Leu14, Lyb8, MGC130020, sialic acid binding Ig like lectin 2, SIGLEC 2, T cell surface antigen Leu 14

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 933

Accession #:

Clonality: Polyclonal

Immunogen: Recombinant Human B-cell receptor CD22 protein

Clone #:

Conjugation: Unconjugated

Swissprot: P20273

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.3

Purification method: Antigen Affinity Purification

Application: IHC

Dilution: IHC 1:100-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CD22 Polyclonal Antibody DataSheet