CD274 Polyclonal Antibody | G-AB-04826

CD274 Polyclonal Antibody | G-AB-04826 | Gentaur Antibodies

Overview: Programmed cell death ligand 1 (CD274, or B7-H1, PD-L1) , is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology

Synonyms: B7 H, B7 H1, B7 homolog 1, B7-H1, B7H, B7H1, CD 274, CD274, CD274 antigen, CD274 molecule, MGC142294, MGC142296, OTTHUMP00000021029, PD L1, PD-L1, PD1L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL 1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1, RGD1566211

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP054862

Clonality: Polyclonal

Immunogen: Synthetic peptide of human CD274

Clone #:

Conjugation: Unconjugated

Swissprot: Q9NZQ7

Santa Cruz:

Calculated MW: 33 kDa

Observed MW: Refer to figures

Concentration: 0.72 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CD274 Polyclonal Antibody DataSheet