CDK5R1 Polyclonal Antibody | G-AB-08703

CDK5R1 Polyclonal Antibody | G-AB-08703 | Gentaur Antibodies

Overview: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) ; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms: CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 8851

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CDK5R1 (NP_003876.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q15078

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CDK5R1 Polyclonal Antibody DataSheet