CHRDL2 Polyclonal Antibody | G-AB-01642

CHRDL2 Polyclonal Antibody | G-AB-01642 | Gentaur Antibodies

Overview: CHRDL2 (chordin-related protein 2) , also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2) , is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Signal Transduction

Synonyms: BNF-1, BNF1, Breast tumor novel factor 1, CHL2, chordin like 2, Chordin like protein 2 precursor, Chordin related protein 2, Chordin-like protein 2, Chordin-related protein 2, Chrdl2, CRDL2, DKFZp586N2124, FKSG37

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_056239

Clonality: Polyclonal

Immunogen: Synthetic peptide of human CHRDL2

Clone #:

Conjugation: Unconjugated

Swissprot: Q6WN34

Santa Cruz: sc-70160

Calculated MW: 48 kDa

Observed MW:

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, ELISA

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CHRDL2 Polyclonal Antibody DataSheet