COASY Polyclonal Antibody | G-AB-07723

COASY Polyclonal Antibody | G-AB-07723 | Gentaur Antibodies

Overview: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and Signal Transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5) . The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA) . Alternative splicing results in multiple isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: COASY, DPCK, NBIA6, NBP, PPAT, UKR1, pOV-2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 80347

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human COASY (NP_079509.5) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13057

Santa Cruz:

Calculated MW: 62 kDa/65 kDa

Observed MW: 62 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

COASY Polyclonal Antibody DataSheet