COMT Polyclonal Antibody | G-AB-04128

COMT Polyclonal Antibody | G-AB-04128 | Gentaur Antibodies

Overview: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT) . The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms: Catechol O methyltransferase, Catechol O-methyltransferase, COMT, COMT, EC 2.1.1.6

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC011935

Clonality: Polyclonal

Immunogen: Fusion protein of human COMT

Clone #:

Conjugation: Unconjugated

Swissprot: P21964

Santa Cruz:

Calculated MW: 30 kDa

Observed MW: Refer to figures

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

COMT Polyclonal Antibody DataSheet