COX10 Polyclonal Antibody | G-AB-01911

COX10 Polyclonal Antibody | G-AB-01911 | Gentaur Antibodies

Overview: Cytochrome c oxidase (COX) , the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K) , is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: 2410004F01Rik, AU042636, COX10, COX10, Cytochrome c oxidase assembly protein, Cytochrome c oxidase subunit X, Heme A farnesyltransferase, Heme O synthase, OTTMUSP00000006085, Protoheme IX farnesyltransferase, mitochondrial, Protoheme IX farnesyltransferase, mitochondrial precursor, RP23-78H18.1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC000060

Clonality: Polyclonal

Immunogen: Recombinant protein of human COX10

Clone #:

Conjugation: Unconjugated

Swissprot: Q12887

Santa Cruz: sc-54061/sc-54061/sc-54062/sc-134792

Calculated MW:

Observed MW:

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

COX10 Polyclonal Antibody DataSheet