CRYAA Polyclonal Antibody | G-AB-10799

CRYAA Polyclonal Antibody | G-AB-10799 | Gentaur Antibodies

Overview: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience, Signal Transduction, Tags & Cell Markers

Synonyms: CRYAA, CRYA1, CTRCT9, HSPB4

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1409

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CRYAA (NP_000385.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P02489

Santa Cruz:

Calculated MW: 19 kDa

Observed MW: 23 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CRYAA Polyclonal Antibody DataSheet