CUL2 Polyclonal Antibody | G-AB-10205

CUL2 Polyclonal Antibody | G-AB-10205 | Gentaur Antibodies

Overview: Human CUL2 is an ortholog of nematode cul2. Michel and Xiong (1998) identified human CUL2 cDNAs and reported that the predicted protein is 745 amino acids long.Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, whicHuman, Mouseediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS (VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) .

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology

Synonyms: CUL2, cullin-2

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 8453

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CUL2 (NP_001185708.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13617

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC, IF

Dilution: IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CUL2 Polyclonal Antibody DataSheet