CYP27B1 Polyclonal Antibody | G-AB-09659

CYP27B1 Polyclonal Antibody | G-AB-09659 | Gentaur Antibodies

Overview: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha, 25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1594

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CYP27B1 (NP_000776.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O15528

Santa Cruz:

Calculated MW: 56 kDa

Observed MW: 63 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:20-1:50

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CYP27B1 Polyclonal Antibody DataSheet