CYP2D6 Polyclonal Antibody | G-AB-01658

CYP2D6 Polyclonal Antibody | G-AB-01658 | Gentaur Antibodies

Overview: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cardiovascular, Metabolism, Signal Transduction

Synonyms: CPD6, CYP2D, CYP2D6, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, Cytochrome P450 DB1, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Debrisoquine 4 hydroxylase, Flavoprotein linked monooxygenase, Microsomal monooxygenase, P450 DB1, P450C2D, P450DB1, Xenobiotic monooxygenase

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_000097

Clonality: Polyclonal

Immunogen: Synthetic peptide of human CYP2D6

Clone #:

Conjugation: Unconjugated

Swissprot: P10635

Santa Cruz: sc-23690

Calculated MW:

Observed MW:

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CYP2D6 Polyclonal Antibody DataSheet