DLAT Polyclonal Antibody | G-AB-08715

DLAT Polyclonal Antibody | G-AB-08715 | Gentaur Antibodies

Overview: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC) . PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC) . In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Signal Transduction

Synonyms: DLAT, DLTA, PDC-E2, PDCE2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1737

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human DLAT (NP_001922.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P10515

Santa Cruz:

Calculated MW: 68 kDa

Observed MW: 69 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

DLAT Polyclonal Antibody DataSheet