DNASE1 Polyclonal Antibody | G-AB-08716
Gentaur Antibodies
- SKU:
- G-AB-08716
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Mouse, Rat
DNASE1 Polyclonal Antibody | G-AB-08716 | Gentaur Antibodies
Overview: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE) , an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism
Synonyms: DNASE1, DNL1, DRNI
Reactivity: Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID: 1773
Accession #:
Clonality:
Immunogen: Recombinant fusion protein of human DNASE1 (NP_005214.2) .
Clone #:
Conjugation: Unconjugated
Swissprot: P24855
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: IF
Dilution: IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.