DOK3 Polyclonal Antibody | G-AB-05113

DOK3 Polyclonal Antibody | G-AB-05113 | Gentaur Antibodies

Overview: DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: Docking protein 3, DOK 3, DOK Like Protein, Dok3, DOK3, DOKL Pending, Downstream of tyrosine kinase 3, p62 DOK Like Protein

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC004564

Clonality: Polyclonal

Immunogen: Fusion protein of human DOK3

Clone #:

Conjugation: Unconjugated

Swissprot: Q7L591

Santa Cruz:

Calculated MW: 53 kDa

Observed MW: Refer to figures

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, ELISA

Dilution: WB 1:500-1:2000, ELISA 1:1000-1:5000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

DOK3 Polyclonal Antibody DataSheet