DUT Polyclonal Antibody | G-AB-01256
Gentaur Antibodies
- SKU:
- G-AB-01256
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Rat
DUT Polyclonal Antibody | G-AB-01256 | Gentaur Antibodies
Overview: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Category Type: Polyclonal Antibody
Research Areas: Epigenetics and Nuclear Signaling
Synonyms: Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isoform, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Deoxyuridine triphosphatase, dut, DUT, dUTP nucleotidohydrolase, dUTP pyrophosphatase, dUTPase, FLJ20622
Reactivity: Human, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: NP_001939
Clonality: Polyclonal
Immunogen: Synthetic peptide of human DUT
Clone #:
Conjugation: Unconjugated
Swissprot: P33316
Santa Cruz: sc-68069/sc-68071/sc-68073
Calculated MW: 27 kDa
Observed MW:
Concentration: 0.2 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:200-1:1000, IHC 1:10-1:50
Storage: Store at -20°C. Avoid freeze / thaw cycles.