DUT Polyclonal Antibody | G-AB-10217

DUT Polyclonal Antibody | G-AB-10217 | Gentaur Antibodies

Overview: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Category Type: Polyclonal Antibody

Research Areas: Epigenetics and Nuclear Signaling

Synonyms: DUT, dUTPase

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 1854

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human DUT (NP_001020419.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P33316

Santa Cruz:

Calculated MW: 17 kDa/26 kDa

Observed MW: 24 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:1000 IHC 1:50-1:200 IF 1:100-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

DUT Polyclonal Antibody DataSheet