E-Cadherin Polyclonal Antibody | G-AB-00244

E-Cadherin Polyclonal Antibody | G-AB-00244 | Gentaur Antibodies

Overview: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Developmental Biology, Signal Transduction

Synonyms: Arc 1, CADH1, Cadherin 1, cadherin 1 type 1 E-cadherin, Cadherin1, CAM 120/80, CD 324, CD324, CD324 antigen, cdh1, CDHE, E-Cad/CTF3, E-cadherin, ECAD, Epithelial cadherin, epithelial calcium dependant adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Recombinant Human Cadherin-1 protein

Clone #:

Conjugation: Unconjugated

Swissprot: P12830

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification method: Antigen Affinity Purification

Application: IHC

Dilution: IHC 1:100-1:400

Storage: Store at -20°C. Avoid freeze / thaw cycles.

E-Cadherin Polyclonal Antibody DataSheet