EDN3 Polyclonal Antibody | G-AB-07395

EDN3 Polyclonal Antibody | G-AB-07395 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB) . The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS) , which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Neuroscience, Signal Transduction

Synonyms: EDN3, ET-3, ET3, HSCR4, PPET3, WS4B

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 1908

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human EDN3 (NP_996917.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P14138

Santa Cruz:

Calculated MW: 23 kDa/25 kDa

Observed MW: 44 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

EDN3 Polyclonal Antibody DataSheet