EID1 Polyclonal Antibody | G-AB-02450

EID1 Polyclonal Antibody | G-AB-02450 | Gentaur Antibodies

Overview: E1A-like inhibitor of differentiation-1 (EID-1) , an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb) , a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: 21 kDa pRb associated protein, 21 kDa pRb-associated protein, C15orf3, CBP, Chromosome 15 open reading frame 3, CREBBP/EP300 inhibitor 1, CREBBP/EP300 inhibitory protein 1, CRI 1, CRI1, E1A like inhibitor of differentiation, E1A-like inhibitor of differentiation 1, EID 1, EID-1, EID1, EID1, EP300 interacting inhibitor of differentiation 1, EP300-interacting inhibitor of differentiation 1, IRO45620, MGC138883, MGC138884, NB4 apoptosis related protein, PNAS 22, PNAS22, PTD014, Rb and p300 binding protein EID 1, Rb and p300 binding protein EID1, RBP21, Retinoblastoma protein associated protein

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_055150

Clonality: Polyclonal

Immunogen: Recombinant protein of human EID1

Clone #:

Conjugation: Unconjugated

Swissprot: Q9Y6B2

Santa Cruz: sc-49002/sc-49003/sc-98923/sc-98922

Calculated MW:

Observed MW:

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

EID1 Polyclonal Antibody DataSheet