ELANE Polyclonal Antibody | G-AB-03658

ELANE Polyclonal Antibody | G-AB-03658 | Gentaur Antibodies

Overview: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN) . This gene is present in a gene cluster on chromosome 19.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology, Microbiology, Signal Transduction

Synonyms: Bone marrow serine protease, ELA2, ELANE, Elastase 2, Elastase 2 neutrophil, Elastase neutrophil expressed, Elastase-2, ELNE, GE, Granulocyte derived elastase, HLE, HNE, Human leukocyte elastase, Leukocyte elastase, Medullasin, NE, Neutrophil elastase, PMN E, PMN elastase, Polymorphonuclear elastase, SCN1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP001963

Clonality: Polyclonal

Immunogen: Synthetic peptide of human ELANE

Clone #:

Conjugation: Unconjugated

Swissprot: P08246

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ELANE Polyclonal Antibody DataSheet