EMP2 Polyclonal Antibody | G-AB-03138

EMP2 Polyclonal Antibody | G-AB-03138 | Gentaur Antibodies

Overview: EMP-2 (epithelial membrane protein 2) , also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Developmental biology, Signal Transduction

Synonyms: EMP 2, EMP-2, EMP2, EMP2, Epithelial membrane protein 2, Protein XMP

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_001415

Clonality: Polyclonal

Immunogen: Synthetic peptide of human EMP2

Clone #:

Conjugation: Unconjugated

Swissprot: P54851

Santa Cruz: sc-101949

Calculated MW:

Observed MW:

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

EMP2 Polyclonal Antibody DataSheet