ERBB3 Polyclonal Antibody | G-AB-07257

ERBB3 Polyclonal Antibody | G-AB-07257 | Gentaur Antibodies

Overview: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 2065

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ERBB3 (NP_001973.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P21860

Santa Cruz:

Calculated MW: 20 kDa/36 kDa/77 kDa/141 kDa/148 kDa

Observed MW: 200 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ERBB3 Polyclonal Antibody DataSheet