ERK 1/2 Polyclonal Antibody | G-AB-05957

ERK 1/2 Polyclonal Antibody | G-AB-05957 | Gentaur Antibodies

Overview: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2) . Phosphorylates SPZ1 (By similarity) . Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction, Neuroscience

Synonyms: MAPK3, ERK1, PRKM3, Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human ERK 1/2 around the non-phosphorylation site of Tyr204.

Clone #:

Conjugation: Unconjugated

Swissprot: P27361, P28482

Santa Cruz:

Calculated MW: 43 kDa

Observed MW: 44+42 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC-p, ELISA

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ERK 1/2 Polyclonal Antibody DataSheet