ERN2 Polyclonal Antibody | G-AB-01680
Gentaur Antibodies
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Gentaur Antibodies
ERN2 Polyclonal Antibody | G-AB-01680
- SKU:
- G-AB-01680
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
ERN2 Polyclonal Antibody | G-AB-01680 | Gentaur Antibodies
Overview: The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein) . IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
Category Type: Polyclonal Antibody
Research Areas: Signal Transduction
Synonyms: IRE1b, IRE1-BETA
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: NP_150296
Clonality: Polyclonal
Immunogen: Synthetic peptide of human ERN2
Clone #:
Conjugation: Unconjugated
Swissprot: Q76MJ5
Santa Cruz: sc-20575/sc-10512/sc-20576/sc-25563
Calculated MW:
Observed MW:
Concentration: 0.5 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: IHC, ELISA
Dilution: IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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