F12 Polyclonal Antibody | G-AB-09582

F12 Polyclonal Antibody | G-AB-09582 | Gentaur Antibodies

Overview: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF) -like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular

Synonyms: F12, HAE3, HAEX, HAF

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 2161

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human F12 (NP_000496.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P00748

Santa Cruz:

Calculated MW: 67 kDa

Observed MW: 71 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

F12 Polyclonal Antibody DataSheet