FADD Polyclonal Antibody | G-AB-10847

FADD Polyclonal Antibody | G-AB-10847 | Gentaur Antibodies

Overview: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology

Synonyms: GIG3, MORT1, FADD, FADD

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 8772

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human FADD (NP_003815.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13158

Santa Cruz:

Calculated MW: 23 kDa

Observed MW: 26 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

FADD Polyclonal Antibody DataSheet