FAS Polyclonal Antibody | G-AB-07142

FAS Polyclonal Antibody | G-AB-07142 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD) , caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD) . The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Immunology

Synonyms: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, FAS

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 355

Accession #:

Clonality:

Immunogen: A synthetic peptide of human FAS (NP_000034.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P25445

Santa Cruz:

Calculated MW: 9 kDa/11 kDa/14 kDa/16 kDa/24 kDa/35 kDa/37 kDa

Observed MW: 38 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

FAS Polyclonal Antibody DataSheet