FURIN Polyclonal Antibody | G-AB-11692

FURIN Polyclonal Antibody | G-AB-11692 | Gentaur Antibodies

Overview: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms: FURIN, FUR, PACE, PCSK3, SPC1, furin

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 5045

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human FURIN (NP_002560.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P09958

Santa Cruz:

Calculated MW: 86 kDa

Observed MW: 80 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

FURIN Polyclonal Antibody DataSheet