GRM2 Polyclonal Antibody | G-AB-07010

GRM2 Polyclonal Antibody | G-AB-07010 | Gentaur Antibodies

Overview: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative Signal Transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Neuroscience

Synonyms: AMPA selective glutamate receptor 2, GLUR2, GLURB, Glutamate metabotropic receptor 2, Glutamate receptor homolog, Glutamate receptor metabotropic 2, GPRC1B, GRM2, GRM2, Metabotropic glutamate receptor 2, mGlu2, mGluR2, OTTHUMP00000210984, OTTHUMP00000210986

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP000830

Clonality: Polyclonal

Immunogen: Synthetic peptide of human GRM2

Clone #:

Conjugation: Unconjugated

Swissprot: Q14416

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.96 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

GRM2 Polyclonal Antibody DataSheet