HLA-B Polyclonal Antibody | G-AB-07945

HLA-B Polyclonal Antibody | G-AB-07945 | Gentaur Antibodies

Overview: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin) . The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Category Type: Polyclonal Antibody

Research Areas: Immunology, Microbiology

Synonyms: HLA-B, AS, B-4901, HLAB, Bw-47, Bw-50, SPDA1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 3106

Accession #:

Clonality:

Immunogen: A synthetic peptide of human HLA-B (NP_005505.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P01889

Santa Cruz:

Calculated MW: 40 kDa

Observed MW: 40 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:1000-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HLA-B Polyclonal Antibody DataSheet