HLA-DMB Polyclonal Antibody | G-AB-06341
Gentaur Antibodies
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Gentaur Antibodies
HLA-DMB Polyclonal Antibody | G-AB-06341
- SKU:
- G-AB-06341
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
HLA-DMB Polyclonal Antibody | G-AB-06341 | Gentaur Antibodies
Overview: HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Category Type: Polyclonal Antibody
Research Areas: Immunology
Synonyms: class II antigen HLA-DM beta chain, class II histocompatibility antigen, Class II histocompatibility antigen M beta chain, D6S221E, DMB, HLA class II histocompatibility antigen DM beta chain, HLA-DM histocompatibility type, beta chain, M beta chain, Major histocompatibility complex class II DM beta, MHC class II antigen DMB, MHC class II antigen HLA DM beta chain, MHC class II HLA DMB, OTTHUMP00000029257, Really interesting new gene 7 protein, RING 7, RING7
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: BC027175
Clonality: Polyclonal
Immunogen: Fusion protein of human HLA-DMB
Clone #:
Conjugation: Unconjugated
Swissprot: P28068
Santa Cruz:
Calculated MW: 29 kDa
Observed MW: Refer to figures
Concentration: 1.38 mg/mL
Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification method: Antigen affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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