HLA-DOB Polyclonal Antibody | G-AB-03793

HLA-DOB Polyclonal Antibody | G-AB-03793 | Gentaur Antibodies

Overview: HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB) , both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: HLA-DOB, HLA class II histocompatibility antigen, DO beta chain, MHC class II antigen DOB

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP002111

Clonality: Polyclonal

Immunogen: Synthetic peptide of human HLA-DOB

Clone #:

Conjugation: Unconjugated

Swissprot: P13765

Santa Cruz:

Calculated MW: 31 kDa

Observed MW: Refer to figures

Concentration: 1.2 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HLA-DOB Polyclonal Antibody DataSheet