HLA-DPB1 Polyclonal Antibody | G-AB-08576

HLA-DPB1 Polyclonal Antibody | G-AB-08576 | Gentaur Antibodies

Overview: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB) , both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Immunology

Synonyms: DPB1, HLA-DP, HLA-DP1B, HLA-DPB, HLA-DPB1, major histocompatibility complex, class II, DP beta 1

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 3115

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human HLA-DPB1 (NP_002112.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: P04440

Santa Cruz:

Calculated MW: 29 kDa

Observed MW: 27-29 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HLA-DPB1 Polyclonal Antibody DataSheet