HLA-DRB1 Polyclonal Antibody | G-AB-03795

HLA-DRB1 Polyclonal Antibody | G-AB-03795 | Gentaur Antibodies

Overview: HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB) , both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: Clone P2-Beta-3, Lymphocyte Antigen DRB1, MHC Class II HLA-DR Beta 1 Chain, SS1, DR1, DRB1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: Hs.534322

Clonality: Polyclonal

Immunogen: Synthetic peptide of human HLA-DRB1

Clone #:

Conjugation: Unconjugated

Swissprot: P20039

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.08 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HLA-DRB1 Polyclonal Antibody DataSheet